AI tool cuts antidepressant drop-out rates by 40%, trial finds

4 March 2026

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By Daniel Pye

A new AI-based tool that personalises antidepressant treatment has significantly reduced the number of people discontinuing their medication, according to results from an international clinical trial.

The PETRUSHKA trial found that patients whose drug type was selected using the digital tool were 40% less likely to stop taking their medication within eight weeks compared to those receiving usual care from their doctor.







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